description

chromosome positioning near the pole and transport through the polar septum / antagonist of SMC complex to the origin of replication

CTP hydrolase, chromosome positioning near the pole and transport through the polar septum / antagonist of SMC complex to the origin of replication, coordination of early steps in DNA replication with establishment of a medial division site

locus

BSU40960

BSU_40960

geneLength

846

849

outlinks

bsu

BSU40960

BSU_40960

The protein

Catalyzed reaction/ biological activity

inhibits [[protein|ParA]] dimerization and concomitant DNA-binding activity by stimulating [[protein|ParA]] ATPase activity [Pubmed|21235642]

recruits the condensin complex to the DNA origin region [Pubmed|24440393]

the dimer binds specifcally to the centromere-like ''parS'' sequence [Pubmed|25572315]

forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation [pubmed|29244022]

inhibits [[protein|ParA]] dimerization and concomitant DNA-binding activity by stimulating [[protein|ParA]] ATPase activity [Pubmed|21235642]

recruits the condensin complex to the DNA origin region [Pubmed|24440393]

the dimer binds specifcally to the centromere-like ''parS'' sequence [Pubmed|25572315]

prevents Z ring assembly over the bacterial nucleoid and helps fine tune the assembly of the Z ring at midcell during the cell cycle [pubmed|31152469]

The protein

Protein family

parB family (according to Swiss-Prot)

ParB family (with [[protein|Noc]], according to UniProt)

The protein

Paralogous protein(s)

[[protein|Noc]]

[[this]]

The protein

Structure

[PDB|4UMK] (complex with ''parS'' DNA)

[PDB|5U1G] [pubmed|28373206]

[PDB|5U1J] [pubmed|28373206]

[PDB|4UMK] (complex with ''parS'' DNA)

[PDB|5U1G] [pubmed|28373206]

[PDB|5U1J] [pubmed|28373206]

[PDB|6SDK] (complex with CDP)

Labs working on this gene/protein

[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]

References

Reviews

22934648, 26706151, 28075389

22934648, 26706151, 28075389, 30863373, 31254421

References

Original publications

17462018, 16677298, 12562803, 10852876, 10482533, 9506522, 8071208, 17932079, 21235642, 26253537, 9663676, 11532141, 15659156, 18854156, 9159397, 8866474, 9778525, 16925562, 1900505, 9364919, 9701805, 12950914, 14651647, 19450517, 19450516, 14563866, 23475963, 21911367, 24440393, 24829297, 24696501, 25071173, 25572315, 25951515, 26295962, 28154080, 28373206, 28407103

17462018, 16677298, 12562803, 10852876, 10482533, 9506522, 8071208, 17932079, 21235642, 26253537, 9663676, 11532141, 15659156, 18854156, 9159397, 8866474, 9778525, 16925562, 1900505, 9364919, 9701805, 12950914, 14651647, 19450517, 19450516, 14563866, 23475963, 21911367, 24440393, 24829297, 24696501, 25071173, 25572315, 25951515, 26295962, 28154080, 28373206, 28407103, 29244022, 16306995, 29378890, 30100265, 30907359, 31152469, 16885474, 31318889

Gene

Phenotypes of a mutant

a [[gene|whiA ]][[gene|parB]] double mutant is not viable, this can be suppressed by inactivation of [[gene|yneA ]][pubmed|29378890]

The protein

[SW|Domains]

N-terminal domain (NTD, aa 1 - 96): binds [[protein|ParA]] [pubmed|10064607]

Central DNA-binding domain (CDBD, aa 102 - 216): binds parS DNA [pubmed|16306995]

C-terminal domain (CTD, aa 233 - 282): binding of non-specific DNA, dimerization, essential for DNA condensation [pubmed|29244022]

labs

[SW|Heath Murray], Centre for Bacterial Cell Biology, Newcastle, UK [http://www.ncl.ac.uk/camb/staff/profile/heath.murray homepage]